Scientists from our Institute, in collaboration with two-time Nobel Prize winner in Chemistry, K. Barry Sharpless, have published a paper in the prestigious journal Archives of Toxicology:
This work continues a long-standing collaboration with scientists from the University of California, San Diego, and The Scripps Research Institute in the field of neuroprotection against chemical agent poisoning. Prof. Sharpless was awarded the Nobel Prize in 2001 for his pioneering work on chirally catalyzed hydrogenation reactions and again in 2022 for the development of click chemistry, an approach that enables the rapid and selective linking of molecules. Compounds designed using this method were tested at our Institute to develop efficient reactivators of butyrylcholinesterase as a biological scavenger for organophosphorus compounds, opening new possibilities for protection against both nerve agents and pesticides commonly encountered in daily life.