{"id":781,"date":"2025-08-13T08:00:00","date_gmt":"2025-08-13T08:00:00","guid":{"rendered":"https:\/\/projekti.imi.hr\/biomoltox\/?p=781"},"modified":"2025-09-08T15:05:27","modified_gmt":"2025-09-08T15:05:27","slug":"photochemistry-driven-design-of-small-molecule-cholinesterase-ligands-2","status":"publish","type":"post","link":"https:\/\/projekti.imi.hr\/biomoltox\/en\/2025\/08\/13\/photochemistry-driven-design-of-small-molecule-cholinesterase-ligands-2\/","title":{"rendered":"Photochemistry-driven design of small molecule cholinesterase ligands"},"content":{"rendered":"\n<p><strong>Authors:\u00a0<\/strong>Irena \u0160kori\u0107, Maja Sviben, Milena Mlaki\u0107, Tena \u010cade\u017e, Nikolina Ma\u010dek Hrvat, Zrinka Kovarik<\/p>\n\n\n\n<p><strong>Abstract<\/strong><br>The development of small-molecule ligands targeting cholinesterases remains a central focus in neuropharmacology, particularly for the treatment of neurodegenerative disorders and organophosphate poisoning. This review highlights the rational design, synthesis, and biological profiling of diverse classes of heterocyclic compounds \u2013 including oxazoles, heterostilbenes, triazoles, and bicyclo[3.2.1]octane\/octadiene derivatives \u2013 as reversible inhibitors and reactivators of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Novel amino-oxazolostilbenes and their photoproducts exhibited selective BChE inhibition, while naphtoxazole and triazole-containing scaffolds demonstrated promising dual-target or BChE-selective profiles. Several uncharged oximes, such as thienostilbene and heterostilbene oximes, showed potential for reactivating cyclosarin-inhibited BChE, supporting their further development as CNS-permeable antidotes. Additionally, resveratrol-based triazoles and carbamates revealed enhanced BChE inhibition, antioxidant activity, and favorable selectivity. Collectively, these findings underscore the therapeutic potential of structurally diverse cholinesterase ligands and provide a framework for the discovery of multifunctional agents for Alzheimer&#8217;s disease and chemical threat countermeasures.<\/p>\n\n\n\n<p>The article is available at the following\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0009279725003333\" data-type=\"link\" data-id=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0009279725003333\" target=\"_blank\" rel=\"noreferrer noopener\">link<\/a>.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors:\u00a0Irena \u0160kori\u0107, Maja Sviben, Milena Mlaki\u0107, Tena \u010cade\u017e, Nikolina Ma\u010dek Hrvat, Zrinka Kovarik AbstractThe development of small-molecule ligands targeting cholinesterases remains a central focus in neuropharmacology, particularly for the treatment of neurodegenerative disorders and organophosphate poisoning. This review highlights the rational design, synthesis, and biological profiling of diverse classes of heterocyclic compounds \u2013 including oxazoles, &hellip;<br \/><a href=\"https:\/\/projekti.imi.hr\/biomoltox\/en\/2025\/08\/13\/photochemistry-driven-design-of-small-molecule-cholinesterase-ligands-2\/\" class=\"more-link pen_button pen_element_default pen_icon_arrow_double\">Continue reading <span class=\"screen-reader-text\">Photochemistry-driven design of small molecule cholinesterase ligands<\/span><\/a><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21],"tags":[],"class_list":["post-781","post","type-post","status-publish","format-standard","hentry","category-pub-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/comments?post=781"}],"version-history":[{"count":1,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/781\/revisions"}],"predecessor-version":[{"id":782,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/781\/revisions\/782"}],"wp:attachment":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/media?parent=781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/categories?post=781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/tags?post=781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}