{"id":710,"date":"2025-03-28T08:00:00","date_gmt":"2025-03-28T08:00:00","guid":{"rendered":"https:\/\/projekti.imi.hr\/biomoltox\/?p=710"},"modified":"2025-04-08T15:20:32","modified_gmt":"2025-04-08T15:20:32","slug":"the-impact-of-resveratrol-and-melatonin-on-the-genome-and-oxidative-status-in-ageing-rats","status":"publish","type":"post","link":"https:\/\/projekti.imi.hr\/biomoltox\/2025\/03\/28\/the-impact-of-resveratrol-and-melatonin-on-the-genome-and-oxidative-status-in-ageing-rats\/","title":{"rendered":"The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats"},"content":{"rendered":"\n<p><strong>Autori:\u00a0<\/strong>Marko Geri\u0107, Lucia Nani\u0107, Vedran Micek, Ivana Novak Jovanovi\u0107, Goran Gajski, Dubravka Ra\u0161i\u0107, Tatjana Orct, Marija Ljubojevi\u0107, Dean Karaica, Jasna Jurasovi\u0107, Ivana Vrhovac Maduni\u0107, Maja Peraica, Ivan Saboli\u0107, Vanessa Moraes de Andrade, Davorka Breljak, Ivica Rubelj<\/p>\n\n\n\n<p><strong>Sa\u017eetak rada<\/strong><br>Background: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the potential geroprotective effects of resveratrol and melatonin in ageing rats. Methods: The animals were treated with these two compounds starting at 3 months of age and continuing until 1 year or 2 years of age. Using a multibiomarker approach, we assessed DNA damage, telomere length, and the oxidative status in their urine, liver, and kidneys. Results: Despite employing this experimental approach, our results did not provide conclusive evidence of geroprotective effects across the evaluated organs. However, we observed sex-dependent differences in response to treatment. Conclusions: Given the high potency of these two compounds, further research is warranted to explore their incorporation into daily routines as a strategy to mitigate ageing-related effects.<\/p>\n\n\n\n<p>Rad je dostupan na sljede\u0107oj\u00a0<a href=\"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1187\" data-type=\"link\" data-id=\"https:\/\/www.mdpi.com\/2072-6643\/17\/7\/1187\" target=\"_blank\" rel=\"noreferrer noopener\">poveznici<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Autori:\u00a0Marko Geri\u0107, Lucia Nani\u0107, Vedran Micek, Ivana Novak Jovanovi\u0107, Goran Gajski, Dubravka Ra\u0161i\u0107, Tatjana Orct, Marija Ljubojevi\u0107, Dean Karaica, Jasna Jurasovi\u0107, Ivana Vrhovac Maduni\u0107, Maja Peraica, Ivan Saboli\u0107, Vanessa Moraes de Andrade, Davorka Breljak, Ivica Rubelj Sa\u017eetak radaBackground: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate &hellip;<br \/><a href=\"https:\/\/projekti.imi.hr\/biomoltox\/2025\/03\/28\/the-impact-of-resveratrol-and-melatonin-on-the-genome-and-oxidative-status-in-ageing-rats\/\" class=\"more-link pen_button pen_element_default pen_icon_arrow_double\">Continue reading <span class=\"screen-reader-text\">The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats<\/span><\/a><\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13],"tags":[],"class_list":["post-710","post","type-post","status-publish","format-standard","hentry","category-pub-hr"],"acf":[],"_links":{"self":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/comments?post=710"}],"version-history":[{"count":1,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/710\/revisions"}],"predecessor-version":[{"id":711,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/posts\/710\/revisions\/711"}],"wp:attachment":[{"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/media?parent=710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/categories?post=710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/projekti.imi.hr\/biomoltox\/wp-json\/wp\/v2\/tags?post=710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}