Category:Publications

Authors: Katarina Matković, Marko Gerić, Luka Kazensky, Mirta Milić, Vilena Kašuba, Ante Cvitković, Mandica Sanković, Antun Šumanovac, Peter Møller, Goran Gajski AbstractThe use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous samples. Proper sample preservation becomes imperative to prevent spurious DNA breakage. Previous research …
Continue reading Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies

Authors: Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik AbstractNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the development …
Continue reading New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Authors: Dora Kolić, Goran Šinko AbstractTriazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry. Here, we evaluate the anticholinesterase effect of the first isopropanol triazole fungicide …
Continue reading Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

Authors: Luka Kazensky, Katarina Matković, Marko Gerić, Bojana Žegura, Gordana Pehnec, Goran Gajski AbstractIndoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households. Burning these fuels produces harmful compounds, such as particulate matter regarded as a major health risk, particularly affecting the …
Continue reading Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review

Authors: Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik Abstract Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood-brain barrier and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may serve as a centrally active ligand of …
Continue reading Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases

Authors: Carina Ladeira, Peter Møller, Lisa Giovannelli, Goran Gajski, Anja Haveric, Ezgi Eyluel Bankoglu, Amaya Azqueta, Marko Gerić, Helga Stopper, José Cabêda, Fernanda S Tonin, Andrew Collins AbstractBiomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection of damage and early disease prevention. In recent years, …
Continue reading The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Authors: Davor Želježić, Goran Kovačević, Ana Matijević, Petra Korać, Katarina Caput Mihalić AbstractThe aim of this paper was to evaluate whether symbiotic cooperation between green hydra (Hydra viridissima) and photoautotrophic alga gives higher resistance of the preservation of DNA integrity compared to brown hydra (Hydra oligactis). Norflurazon concentrations were 0.061 or 0.61 mg/L and UV-B light 254 nm, …
Continue reading Does the Symbiotic Relationship Between Hydra Viridissima and Photoautotrophic Alga Provide an Evolutionary Advantage in Protecting DNA against Damage by the Cytotoxic or Genotoxic Mode of Action of Environmental Stressors?

Authors: Dora Kolić, Vesna Pehar, Zrinka Kovarik AbstractGlyphosate has remained the leading herbicide on the global market to date, despite the continuous debate between consumers, scientific community, and regulatory agencies over its carcinogenicity, genotoxicity, environmental persistence, and the role in the development of neurodegenerative disorders. Chemically, glyphosate belongs to a large family of organophosphorus pesticides, which …
Continue reading Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase

Authors: Goran Gajski, Vilena Kašuba, Mirta Milić, Marko Gerić, Katarina Matković, Luka Delić, Maja Nikolić, Martina Pavičić, Ružica Rozgaj, Vera Garaj-Vrhovac, Nevenka Kopjar AbstractIn this study, we used the cytokinesis-block micronucleus (CBMN) assay to evaluate the background frequency of cytogenetic damage in peripheral blood lymphocytes of the general population concerning different anthropometric data and lifestyle factors. …
Continue reading Exploring cytokinesis block micronucleus assay in Croatia: A journey through the past, present, and future in biomonitoring of the general population