Category:Publications

Authors: Mario Lovrić, Goran Gajski, Jessica Fernández‐Agüera, Mira Pöhlker, Heimo Gursch, Alex Borg, Jon Switters, Francesco Mureddu, EDIAQI Consortium AbstractIndoor air pollution is a recognized emerging threat, claiming millions of lives annually. People are constantly exposed to ambient and indoor air pollution. The latest research shows that people in developed countries spend up to 90% …
Continue reading Evidence-driven indoor air quality improvement: An innovative and interdisciplinary approach to improving indoor air quality

Authors: Davorka Repac Antić, Bruno Kovač, Marko Kolenc, Irena Brčić Karačonji, Ivana Gobin, Mirna Petković Didović AbstractEnterococcus faecalis, responsible for a majority of human and nosocomial enterococcal infections, is intrinsically resistant to aminoglycoside antibiotics (such as gentamicin, GEN), which must be used in a combined therapy to be effective. Nitroxoline (NTX) is an old antibiotic, …
Continue reading Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections

Authors: Vesna Benković*, Ines Tkalčec, Anica Knežević, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Nevenka Kopjar AbstractThe antioxidant properties of the leaves of the Mediterranean strawberry tree (Arbutus unedo L.) are mainly attributed to the main bioactive compound, the phenolic glycoside arbutin. In this study, the safety profile of strawberry tree aqueous leaf extract (STE) and …
Continue reading Effects of Strawberry Tree (Arbutus unedo L.) Aqueous Leaf Extract and Arbutin on PK-15 and HepG2 Cells

Authors: Vesna Benković*, Dora Vuković, Iva Đelatić, Vanja Popović, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Ana Lucić Vrdoljak, Nevenka Kopjar AbstractThere is growing evidence that arbutin and plant extracts rich in arbutin, such as extracts of the strawberry tree (Arbutus unedo L.), exert a range of beneficial effects, including cyto- and genoprotective properties. This study …
Continue reading Effects of Strawberry Tree Water Leaf Extract and Arbutin on Biochemical Markers and DNA Integrity in Brain Cells of Lewis Rats

Authors: Ana Matošević, Marija Bartolić, Nikola Maraković, Antonio Zandona, Rajo Petrić, Dejan Opsenica, Anita Bosak AbstractAlzheimer’s disease is age-related multifactorial neurodegenerative disease manifested by gradual loss of memory, cognitive decline and changes in personality. Due to rapid and continuous growth of its prevalence, the treatment of Alzheimer’s disease calls for development of new and efficacies …
Continue reading Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal aminogroup on anticholinesterase and BACE1 activity

Authors: Anja Katić*, Irena Brčić Karačonji, Vedran Micek, Davor Želježić AbstractGreen agronomy promotes the implementation of natural and naturally derived substances in crop protection. In the present study, we evaluated the endocrine-disrupting potential of the allelopathic herbicide tembotrione in Wistar rats by studying the hormone status of offspring from the treated dams. Three doses of tembotrione …
Continue reading Endocrine-Disrupting Effects of Transplacental and Translactational Exposure to Tembotrione on Hormone Status in Wistar Rat Offspring at Different Developmental Stages: A Pilot Study

Authors: Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik AbstractNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the development …
Continue reading New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Authors: Dora Kolić, Goran Šinko AbstractTriazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry. Here, we evaluate the anticholinesterase effect of the first isopropanol triazole fungicide …
Continue reading Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

Authors: Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik Abstract Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood-brain barrier and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may serve as a centrally active ligand of …
Continue reading Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases