Author:jmadunic

Authors: Vesna Benković*, Ines Tkalčec, Anica Knežević, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Nevenka Kopjar AbstractThe antioxidant properties of the leaves of the Mediterranean strawberry tree (Arbutus unedo L.) are mainly attributed to the main bioactive compound, the phenolic glycoside arbutin. In this study, the safety profile of strawberry tree aqueous leaf extract (STE) and …
Continue reading Effects of Strawberry Tree (Arbutus unedo L.) Aqueous Leaf Extract and Arbutin on PK-15 and HepG2 Cells

Authors: Vesna Benković*, Dora Vuković, Iva Đelatić, Vanja Popović, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Ana Lucić Vrdoljak, Nevenka Kopjar AbstractThere is growing evidence that arbutin and plant extracts rich in arbutin, such as extracts of the strawberry tree (Arbutus unedo L.), exert a range of beneficial effects, including cyto- and genoprotective properties. This study …
Continue reading Effects of Strawberry Tree Water Leaf Extract and Arbutin on Biochemical Markers and DNA Integrity in Brain Cells of Lewis Rats

Authors: Goran Kovačević, Petra Korać, Davor Želježić, Mirela Sertić Perić, Petra Peharec Štefanić, Damir Sirovina, Maja Novosel, Sanja Gottstein AbstractHydra is known for its natural occurrence, anatomical simplicity, intricate physiology, regenerative capacity, and ease of maintenance and manipulation in laboratory environments. It has proven to be a valuable model organism in various disciplines. Its applications range from …
Continue reading Hydra for 21st Century—A Fine Model in Freshwater Research

Authors: Katarina Matković, Marko Gerić, Luka Kazensky, Mirta Milić, Vilena Kašuba, Ante Cvitković, Mandica Sanković, Antun Šumanovac, Peter Møller, Goran Gajski AbstractThe use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous samples. Proper sample preservation becomes imperative to prevent spurious DNA breakage. Previous research …
Continue reading Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies

Authors: Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik AbstractNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the development …
Continue reading New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Authors: Dora Kolić, Goran Šinko AbstractTriazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry. Here, we evaluate the anticholinesterase effect of the first isopropanol triazole fungicide …
Continue reading Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

Authors: Luka Kazensky, Katarina Matković, Marko Gerić, Bojana Žegura, Gordana Pehnec, Goran Gajski AbstractIndoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households. Burning these fuels produces harmful compounds, such as particulate matter regarded as a major health risk, particularly affecting the …
Continue reading Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review

Authors: Carina Ladeira, Peter Møller, Lisa Giovannelli, Goran Gajski, Anja Haveric, Ezgi Eyluel Bankoglu, Amaya Azqueta, Marko Gerić, Helga Stopper, José Cabêda, Fernanda S Tonin, Andrew Collins AbstractBiomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection of damage and early disease prevention. In recent years, …
Continue reading The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Authors: Davor Želježić, Goran Kovačević, Ana Matijević, Petra Korać, Katarina Caput Mihalić AbstractThe aim of this paper was to evaluate whether symbiotic cooperation between green hydra (Hydra viridissima) and photoautotrophic alga gives higher resistance of the preservation of DNA integrity compared to brown hydra (Hydra oligactis). Norflurazon concentrations were 0.061 or 0.61 mg/L and UV-B light 254 nm, …
Continue reading Does the Symbiotic Relationship Between Hydra Viridissima and Photoautotrophic Alga Provide an Evolutionary Advantage in Protecting DNA against Damage by the Cytotoxic or Genotoxic Mode of Action of Environmental Stressors?