Author:jmadunic

Authors: Maja Lazarus, Agnieszka Sergiel, Tatjana Orct, Maja Ferenčaković, Blanka Tariba Lovaković, Suzana Žunec, Dubravka Rašić, Ena Oster, Slaven Reljić, Joanna Macur, Đuro Huber AbstractInduction of oxidative stress and the associated lipid peroxidation is a prevalent mechanism through which certain metal(loid)s exert nephrotoxic effects in mammals. Research on the toxic impacts of metal(loid)s in free-ranging large …
Continue reading Apex carnivores coping with metal(loid) pollution and oxidative stress: Biological and environmental drivers of variation in kidney of European brown bear

Authors: Goran Gajski, Marko Gerić, Ana Baričević, Mirta Smodlaka Tanković AbstractIn this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human …
Continue reading Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

Authors: Davorka Repac Antić, Bruno Kovač, Marko Kolenc, Irena Brčić Karačonji, Ivana Gobin, Mirna Petković Didović AbstractEnterococcus faecalis, responsible for a majority of human and nosocomial enterococcal infections, is intrinsically resistant to aminoglycoside antibiotics (such as gentamicin, GEN), which must be used in a combined therapy to be effective. Nitroxoline (NTX) is an old antibiotic, …
Continue reading Combinatory Effect of Nitroxoline and Gentamicin in the Control of Uropathogenic Enterococci Infections

Authors: Vesna Benković*, Ines Tkalčec, Anica Knežević, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Nevenka Kopjar AbstractThe antioxidant properties of the leaves of the Mediterranean strawberry tree (Arbutus unedo L.) are mainly attributed to the main bioactive compound, the phenolic glycoside arbutin. In this study, the safety profile of strawberry tree aqueous leaf extract (STE) and …
Continue reading Effects of Strawberry Tree (Arbutus unedo L.) Aqueous Leaf Extract and Arbutin on PK-15 and HepG2 Cells

Authors: Vesna Benković*, Dora Vuković, Iva Đelatić, Vanja Popović, Karlo Jurica, Fabijan Knežević, Irena Brčić Karačonji, Ana Lucić Vrdoljak, Nevenka Kopjar AbstractThere is growing evidence that arbutin and plant extracts rich in arbutin, such as extracts of the strawberry tree (Arbutus unedo L.), exert a range of beneficial effects, including cyto- and genoprotective properties. This study …
Continue reading Effects of Strawberry Tree Water Leaf Extract and Arbutin on Biochemical Markers and DNA Integrity in Brain Cells of Lewis Rats

Authors: Goran Kovačević, Petra Korać, Davor Želježić, Mirela Sertić Perić, Petra Peharec Štefanić, Damir Sirovina, Maja Novosel, Sanja Gottstein AbstractHydra is known for its natural occurrence, anatomical simplicity, intricate physiology, regenerative capacity, and ease of maintenance and manipulation in laboratory environments. It has proven to be a valuable model organism in various disciplines. Its applications range from …
Continue reading Hydra for 21st Century—A Fine Model in Freshwater Research

Authors: Katarina Matković, Marko Gerić, Luka Kazensky, Mirta Milić, Vilena Kašuba, Ante Cvitković, Mandica Sanković, Antun Šumanovac, Peter Møller, Goran Gajski AbstractThe use of the comet assay in large biomonitoring studies may present logistical and technical challenges because of the processing of numerous samples. Proper sample preservation becomes imperative to prevent spurious DNA breakage. Previous research …
Continue reading Comparison of DNA damage in fresh and frozen blood samples: implications for the comet assay in human biomonitoring studies

Authors: Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik AbstractNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the development …
Continue reading New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Authors: Dora Kolić, Goran Šinko AbstractTriazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry. Here, we evaluate the anticholinesterase effect of the first isopropanol triazole fungicide …
Continue reading Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin