Author:jmadunic

Authors: Elizabeta Zandona, Maja Vukelić, Karla Hanousek Čiča, Antonio Zandona, Jasna Mrvčić, Maja Katalinić, Ines Cindrić, Almir Abdurramani, Irena Barukčić Jurina AbstractThe food industry generates large quantities of biowaste, including olive (Olea europaea L.) leaves, which are rich in phenolic compounds with proven antioxidant and antimicrobial activity. In this study, a microwave-assisted olive leaf extract was produced …
Continue reading Bioactive Properties of the Microwave-Assisted Olive Leaf Extract and Its Incorporation into a Whey Protein Isolate Coating of Semi-Hard Cheese

Authors: Antonio Zandona, Matea Jurić, Ludovic Jean, Pierre-Yves Renard, Maja Katalinić AbstractTetrahydroisoquinoline (THIQ) oximes have been investigated as antidotes for poisoning by toxic organophosphorus compounds. Recent studies have shown that some THIQ oximes induce cytotoxic effects and trigger apoptosis in various cell types. Since this pathway activation is desirable for anticancer drugs, we further explored the effects …
Continue reading Assessment of cytotoxic properties of tetrahydroisoquinoline oximes in breast, prostate and glioblastoma cancer cells

Authors: Antonio Zandona, Anikó Szecskó, Suzana Žunec, Ivana Novak Jovanović, Valentina Bušić, Dajana Gašo Sokač, Mária A. Deli, Maja Katalinić, Szilvia Veszelka AbstractNicotinamides play a crucial role in energy metabolism and maintenance of the redox homeostasis counteracting oxidative stress and elevated reactive oxidative species (ROS) in human cells. The levels of nicotinamides decline with age and are associated with various pathologies, including ones linked with the blood-brain barrier disorder. Therefore, the investigation …
Continue reading Nicotinamide derivatives protect the blood-brain barrier against oxidative stress

Authors: Marko Gerić, Lucia Nanić, Vedran Micek, Ivana Novak Jovanović, Goran Gajski, Dubravka Rašić, Tatjana Orct, Marija Ljubojević, Dean Karaica, Jasna Jurasović, Ivana Vrhovac Madunić, Maja Peraica, Ivan Sabolić, Vanessa Moraes de Andrade, Davorka Breljak, Ivica Rubelj AbstractBackground: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the …
Continue reading The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats

Authors: Mateo Jakac, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka, Nevenka Kopjar AbstractPropolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since phenolics …
Continue reading Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro

Authors: Tena Čadež, Nikolina Maček Hrvat, Goran Šinko, Jarosław Kalisiak, Zoran Radić, Valery V. Fokin, Karl Barry Sharpless, Palmer Taylor, Zrinka Kovarik AbstractA library of 100 click-chemistry-derived oximes was evaluated as reactivators of butyrylcholinesterase (BChE) inhibited by the nerve agents (NAs) sarin, cyclosarin, VX, and tabun. While reactivation efficiency was highly dependent on the structure of …
Continue reading Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging

Authors: Irena Brčić Karačonji, Tea Jelača, Andreja Jurič, Ana Lucić Vrdoljak AbstractOpiates such as morphine and codeine are substances often misused to improve the performance of racing horses during competitions and are therefore on the International Federation for Equestrian Sports’ list of prohibited substances. However, a positive antidoping test may be due to the consumption of …
Continue reading Morphine and codeine in racing horse feed: is there reason for concern?