Author:jmadunic

Authors: Antonio Zandona, Andreja Jurič, Blanka Tariba Lovaković, Alica Pizent, Dubravka Rašić, Nevenka Kopjar, Maja Katalinić, Arnes Rešić, Irena Canjuga, Marijana Neuberg, Goran Kozina, Ana Lucić Vrdoljak, Irena Brčić Karačonji AbstractAmphetamine-type stimulants (ATSs) are widely abused substances that impair central and peripheral nervous system functions. The mechanisms of their toxicity on human neuronal cells have not …
Continue reading Exposure of human neuroblastoma SH-SY5Y cells to amphetamine-type stimulants leads to oxidative-antioxidative imbalance associated with DNA damage and acetylcholine antagonism

Authors: Ana-Marija Lulić, Lucija Marcelić, Alma Ramić, Andreja Radman Kastelic, Antonio Zandona, Nikola Maraković, Ines Primožič, Maja Katalinić AbstractIn this study, we investigated the inhibitory activity of novel dodecylaminoquinuclidines (QAs) on neurotransmitter-hydrolyzing enzymes, specifically acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Following our previous findings, we modified the structure of a lead compound to develop more potent modulators …
Continue reading Cholinesterase activity modulators: Evaluation of dodecylaminoquinuclidines as inhibitors of human AChE and BChE

Authors: Ana Barbarić, Lara Saftić Martinović, Zvonimir Marijanović, Lea Juretić, Andreja Jurič, Danijela Petrović, Violeta Šoljić, Ivana Gobin AbstractHoneydew honey (HH) is a distinctive type of honey known for its dark colour, high mineral and polyphenol content, and pronounced biological activity. This study continues previous research on beech and chestnut honeydew honeys by presenting a comprehensive …
Continue reading Integrated Chemical and Biological Evaluation of Linden Honeydew Honey from Bosnia and Herzegovina: Composition and Cellular Effects

Authors: Suzana Žunec, Marija Kuzmić, Andreja Jurič, Irena Brčić Karačonji, Ana Lucić Vrdoljak, Nevenka Kopjar AbstractIntroduction: Ultraviolet B (UVB) radiation is a physical agent ubiquitously present in the environment that triggers inflammatory processes, oxidative stress, and DNA instability, potentially leading to various pathological conditions and diseases. In this study, we assessed whether Croatian certified organic chestnut …
Continue reading The protective effect of chestnut honey against oxidative stress and cyto/genotoxicity produced by UVB irradiation established in vitro

Authors: Elizabeta Zandona, Maja Vukelić, Karla Hanousek Čiča, Antonio Zandona, Jasna Mrvčić, Maja Katalinić, Ines Cindrić, Almir Abdurramani, Irena Barukčić Jurina AbstractThe food industry generates large quantities of biowaste, including olive (Olea europaea L.) leaves, which are rich in phenolic compounds with proven antioxidant and antimicrobial activity. In this study, a microwave-assisted olive leaf extract was produced …
Continue reading Bioactive Properties of the Microwave-Assisted Olive Leaf Extract and Its Incorporation into a Whey Protein Isolate Coating of Semi-Hard Cheese

Authors: Antonio Zandona, Matea Jurić, Ludovic Jean, Pierre-Yves Renard, Maja Katalinić AbstractTetrahydroisoquinoline (THIQ) oximes have been investigated as antidotes for poisoning by toxic organophosphorus compounds. Recent studies have shown that some THIQ oximes induce cytotoxic effects and trigger apoptosis in various cell types. Since this pathway activation is desirable for anticancer drugs, we further explored the effects …
Continue reading Assessment of cytotoxic properties of tetrahydroisoquinoline oximes in breast, prostate and glioblastoma cancer cells

Authors: Antonio Zandona, Anikó Szecskó, Suzana Žunec, Ivana Novak Jovanović, Valentina Bušić, Dajana Gašo Sokač, Mária A. Deli, Maja Katalinić, Szilvia Veszelka AbstractNicotinamides play a crucial role in energy metabolism and maintenance of the redox homeostasis counteracting oxidative stress and elevated reactive oxidative species (ROS) in human cells. The levels of nicotinamides decline with age and are associated with various pathologies, including ones linked with the blood-brain barrier disorder. Therefore, the investigation …
Continue reading Nicotinamide derivatives protect the blood-brain barrier against oxidative stress

Authors: Marko Gerić, Lucia Nanić, Vedran Micek, Ivana Novak Jovanović, Goran Gajski, Dubravka Rašić, Tatjana Orct, Marija Ljubojević, Dean Karaica, Jasna Jurasović, Ivana Vrhovac Madunić, Maja Peraica, Ivan Sabolić, Vanessa Moraes de Andrade, Davorka Breljak, Ivica Rubelj AbstractBackground: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate the …
Continue reading The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats