Authors: Mateo Jakac, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka, Nevenka Kopjar AbstractPropolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since phenolics …
Continue reading Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
Author:jmadunic
Publication of a Scientific Paper in Collaboration with Nobel Laureate K. Barry Sharpless
Scientists from our Institute, in collaboration with two-time Nobel Prize winner in Chemistry, K. Barry Sharpless, have published a paper in the prestigious journal Archives of Toxicology: Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging This work continues a long-standing collaboration with scientists from the University of California, San …
Continue reading Publication of a Scientific Paper in Collaboration with Nobel Laureate K. Barry Sharpless
Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging
Authors: Tena Čadež, Nikolina Maček Hrvat, Goran Šinko, Jarosław Kalisiak, Zoran Radić, Valery V. Fokin, Karl Barry Sharpless, Palmer Taylor, Zrinka Kovarik AbstractA library of 100 click-chemistry-derived oximes was evaluated as reactivators of butyrylcholinesterase (BChE) inhibited by the nerve agents (NAs) sarin, cyclosarin, VX, and tabun. While reactivation efficiency was highly dependent on the structure of …
Continue reading Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging
Characterization and differentiation of beech and chestnut honeydew honeys: A comparative study
Authors: Ana Barbarić, Lara Saftić Martinović, Danijel D. Milinčić, Mirjana B. Pešić, Zvonimir Marijanović, Mateo Jakac, Irena Brčić Karačonji, Helena Brekalo, Danijela Petrović, Tomislav Pavlešić, Dijana Mišetić Ostojić, Ivana Gobin AbstractThis study compares beech (Fagus sylvatica) and chestnut (Castanea sativa) honeydew honeys through analyses of physicochemical properties, pollen composition, phenolic and volatile compounds, and bioactivity. Beech …
Continue reading Characterization and differentiation of beech and chestnut honeydew honeys: A comparative study
Ambient air pollution and carcinogenic activity at three different urban locations
Authors: Ivana Jakovljević, Zdravka Sever Štrukil, Gordana Pehnec, Tajana Horvat, Mandica Sanković, Antun Šumanovac, Silvije Davila, Nikolina Račić, Goran Gajski AbstractMeasurements of polycyclic aromatic hydrocarbons (PAHs) were simultaneously carried out at three different urban locations in Croatia (Zagreb, Slavonski Brod and Vinkovci) characterized as urban residential (UR), urban industrial (UI) and urban background (UB), respectively. This …
Continue reading Ambient air pollution and carcinogenic activity at three different urban locations
What is more common in fatal caffeine intoxication – suicide or unintentional overdose?
Authors: Dražen Lušić, Sara Beza, Irena Brčić Karačonji AbstractCaffeine is a natural stimulant of plant origin found in many products such as coffee, tea, chocolate, and energy drinks. It is also often used as an active substance in over-the-counter drugs such as painkillers and preparations for the treatment of colds and allergies. While caffeine is generally …
Continue reading What is more common in fatal caffeine intoxication – suicide or unintentional overdose?
The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage
Authors: Mirta Milić, Luka Kazensky, Martina Matovinović AbstractThe prevalence of metabolic syndrome (MetS) worldwide is rapid and significant on a global scale. A 2022 meta-analysis of data from 28 million individuals revealed a global prevalence of 45.1%, with notably higher rates in the Eastern Mediterranean Region and the Americas, particularly in high-income countries. MetS is associated …
Continue reading The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage
Evaluating air pollution and BTEX exposure effects on DNA damage: A human biomonitoring study in Zagreb, Croatia
Authors: Katarina Matković, Andreja Jurič, Ivana Jakovljević, Luka Kazensky, Mirta Milić, Vilena Kašuba, Silvije Davila, Gordana Pehnec, Irena Brčić Karačonji, Ante Cvitković, Pascal Wild, Irina Guseva Canu, Nancy B. Hopf, Goran Gajski, Marko Gerić AbstractAir pollution, a major global issue, comprises various solid and gaseous pollutants in urban environments, including particulate matter (PM) and volatile organic …
Continue reading Evaluating air pollution and BTEX exposure effects on DNA damage: A human biomonitoring study in Zagreb, Croatia
Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes
Authors: Dubravka Rašić, Antonio Zandona, Maja Katalinić, Martin Češi, Nevenka Kopjar AbstractNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the development …
Continue reading Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes