The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Posted on Updated on by jmadunicCategories:Publications

Authors: Carina Ladeira, Peter Møller, Lisa Giovannelli, Goran Gajski, Anja Haveric, Ezgi Eyluel Bankoglu, Amaya Azqueta, Marko Gerić, Helga Stopper, José Cabêda, Fernanda S Tonin, Andrew Collins

Abstract
Biomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection of damage and early disease prevention. In recent years, the comet assay has become an important tool for assessing DNA damage, both in environmental and occupational exposure contexts. To evidence the role of the comet assay in human biomonitoring, we have analysed original research studies of environmental or occupational exposure that used the comet assay in their assessments, following the PRISMA-ScR method (preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews). Groups of chemicals were designated according to a broad classification, and the results obtained from over 300 original studies (n = 123 on air pollutants, n = 14 on anaesthetics, n = 18 on antineoplastic drugs, n = 57 on heavy metals, n = 59 on pesticides, and n = 49 on solvents) showed overall higher values of DNA strand breaks in the exposed subjects in comparison with the unexposed. In summary, our systematic scoping review strengthens the relevance of the use of the comet assay in assessing DNA damage in human biomonitoring studies.

The article is available at the following link.

jmadunic

1,452 thoughts on “The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review”

  599. I don’t think the title of your article matches the content lol. Just kidding, mainly because I had some doubts after reading the article.

  908. Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.

  1132. Why wait to win big? Join now and experience the best in online gaming with top-notch security, fair play, and thrilling rewards every day!!.Tongits go

  1344. Live the legend with Playtech Live Casino at Casino Plus! Play poker, roulette, and more with real dealers in real-time. It’s smooth, social, and sophisticated—perfect for Filipino players who want the thrill of Vegas, right at home. Playtech

  1358. Barbie Imperial lights up every Pula Puti and Color Game livestream with her signature charm and bubbly personality. As the official face of Casino Plus, she turns every game into a fun, interactive experience that keeps players coming back for more. Catch Barbie Imperial live and let her hype boost your lucky streak! Barbie Imperial

  1436. I’ve recently started playing at WinCraft Casino, and I have to say I’m impressed with how well it’s put together. The website is smooth, easy to navigate, and works perfectly on mobile. There’s a huge variety of games — from classic slots to immersive live dealer tables. What really caught my attention is how seamless the payment system is, especially with the option to use crypto alongside traditional methods. For anyone looking for a reliable and entertaining online casino, this is a solid choice. Check it out here: https://wincraftcasino.net/

  1437. I’ve tried a lot of different online casinos over the years, and WinCraft Casino stands out for its combination of variety, security, and customer experience. The platform is optimized for mobile, meaning I can play my favorite slots and tables wherever I am. Payments are secure and lightning fast, and I really appreciate that they include cryptocurrency options. The live dealer games are also top-notch, creating a truly immersive environment. For anyone considering giving it a try, here’s the link: https://win-craftcasino.com

  1439. WinCraft Casino really surprised me in a good way. The website design is clean, navigation is smooth, and the gameplay is seamless whether I’m on my phone or laptop. The bonuses are valuable, and the loyalty system keeps me motivated to come back. The live dealer games were my favorite — professional dealers and a highly interactive environment. For anyone curious, here’s the link: https://wincraft-casino.org

Leave a Reply

Your email address will not be published. Required fields are marked *