Autor:jmadunic

Autori: Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik Sažetak radaNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the …
Nastavite čitati New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Autori: Dora Kolić, Goran Šinko Sažetak radaTriazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry. Here, we evaluate the anticholinesterase effect of the first isopropanol triazole …
Nastavite čitati Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

Autori: Luka Kazensky, Katarina Matković, Marko Gerić, Bojana Žegura, Gordana Pehnec, Goran Gajski Sažetak radaIndoor air pollution is becoming a rising public health problem and is largely resulting from the burning of solid fuels and heating in households. Burning these fuels produces harmful compounds, such as particulate matter regarded as a major health risk, particularly affecting …
Nastavite čitati Impact of indoor air pollution on DNA damage and chromosome stability: a systematic review

Autori: Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik Sažetak radaOlesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood-brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may serve as a centrally active ligand of acetylcholinesterase …
Nastavite čitati Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases

Autori: Carina Ladeira, Peter Møller, Lisa Giovannelli, Goran Gajski, Anja Haveric, Ezgi Eyluel Bankoglu, Amaya Azqueta, Marko Gerić, Helga Stopper, José Cabêda, Fernanda S Tonin, Andrew Collins Sažetak radaBiomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens, may enable the detection of damage and early disease prevention. In recent …
Nastavite čitati The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals—A Systematic Scoping Review

Autori: Davor Želježić, Goran Kovačević, Ana Matijević, Petra Korać, Katarina Caput Mihalić Sažetak radaThe aim of this paper was to evaluate whether symbiotic cooperation between green hydra (Hydra viridissima) and photoautotrophic alga gives higher resistance of the preservation of DNA integrity compared to brown hydra (Hydra oligactis). Norflurazon concentrations were 0.061 or 0.61 mg/L and UV-B light …
Nastavite čitati Does the Symbiotic Relationship Between Hydra Viridissima and Photoautotrophic Alga Provide an Evolutionary Advantage in Protecting DNA against Damage by the Cytotoxic or Genotoxic Mode of Action of Environmental Stressors?