Autori: Mateo Jakac, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka, Nevenka Kopjar Sažetak radaPropolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since …
Nastavite čitati Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro
Autor:jmadunic
Znanstvena suradnja s dvostrukim nobelovcem K. Barryjem Sharplessom
Djelatnici našeg Instituta, u suradnji s dvostrukim dobitnikom Nobelove nagrade iz kemije K. Barryjem Sharplessom, objavili su rad u vrhunskom časopisu Archieves of Toxicology: Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging Rad je nastavak dugogodišnje suradnje s kalifornijskim znanstvenicima s University of California at San Diego i The …
Nastavite čitati Znanstvena suradnja s dvostrukim nobelovcem K. Barryjem Sharplessom
Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging
Autori: Tena Čadež, Nikolina Maček Hrvat, Goran Šinko, Jarosław Kalisiak, Zoran Radić, Valery V. Fokin, Karl Barry Sharpless, Palmer Taylor, Zrinka Kovarik Sažetak radaA library of 100 click-chemistry-derived oximes was evaluated as reactivators of butyrylcholinesterase (BChE) inhibited by the nerve agents (NAs) sarin, cyclosarin, VX, and tabun. While reactivation efficiency was highly dependent on the structure …
Nastavite čitati Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging
Characterization and differentiation of beech and chestnut honeydewhoneys: A comparative study
Autori: Ana Barbarić, Lara Saftić Martinović, Danijel D. Milinčić, Mirjana B. Pešić, Zvonimir Marijanović, Mateo Jakac, Irena Brčić Karačonji, Helena Brekalo, Danijela Petrović, Tomislav Pavlešić, Dijana Mišetić Ostojić, Ivana Gobin Sažetak radaThis study compares beech (Fagus sylvatica) and chestnut (Castanea sativa) honeydew honeys through analyses of physicochemical properties, pollen composition, phenolic and volatile compounds, and bioactivity. …
Nastavite čitati Characterization and differentiation of beech and chestnut honeydewhoneys: A comparative study
Ambient air pollution and carcinogenic activity at three different urban locations
Autori: Ivana Jakovljević, Zdravka Sever Štrukil, Gordana Pehnec, Tajana Horvat, Mandica Sanković, Antun Šumanovac, Silvije Davila, Nikolina Račić, Goran Gajski Sažetak radaMeasurements of polycyclic aromatic hydrocarbons (PAHs) were simultaneously carried out at three different urban locations in Croatia (Zagreb, Slavonski Brod and Vinkovci) characterized as urban residential (UR), urban industrial (UI) and urban background (UB), respectively. …
Nastavite čitati Ambient air pollution and carcinogenic activity at three different urban locations
What is more common in fatal caffeine intoxication – suicide or unintentional overdose?
Autori: Dražen Lušić, Sara Beza, Irena Brčić Karačonji Sažetak radaCaffeine is a natural stimulant of plant origin found in many products such as coffee, tea, chocolate, and energy drinks. It is also often used as an active substance in over-the-counter drugs such as painkillers and preparations for the treatment of colds and allergies. While caffeine is …
Nastavite čitati What is more common in fatal caffeine intoxication – suicide or unintentional overdose?
The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage
Autori: Mirta Milić, Luka Kazensky, Martina Matovinović Sažetak radaThe prevalence of metabolic syndrome (MetS) worldwide is rapid and significant on a global scale. A 2022 meta-analysis of data from 28 million individuals revealed a global prevalence of 45.1%, with notably higher rates in the Eastern Mediterranean Region and the Americas, particularly in high-income countries. MetS is …
Nastavite čitati The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage
Evaluating air pollution and BTEX exposure effects on DNA damage: A human biomonitoring study in Zagreb, Croatia
Autori: Katarina Matković, Andreja Jurič, Ivana Jakovljević, Luka Kazensky, Mirta Milić, Vilena Kašuba, Silvije Davila, Gordana Pehnec, Irena Brčić Karačonji, Ante Cvitković, Pascal Wild, Irina Guseva Canu, Nancy B. Hopf, Goran Gajski, Marko Gerić Sažetak radaAir pollution, a major global issue, comprises various solid and gaseous pollutants in urban environments, including particulate matter (PM) and volatile …
Nastavite čitati Evaluating air pollution and BTEX exposure effects on DNA damage: A human biomonitoring study in Zagreb, Croatia
Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes
Autori: Dubravka Rašić, Antonio Zandona, Maja Katalinić, Martin Češi, Nevenka Kopjar Sažetak radaNew furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus compound (OP) poisonings. Treating patients with acute OP poisoning is still a challenge despite the …
Nastavite čitati Assessing the Potential Synergistic/Antagonistic Effects of Citrinin and Cannabidiol on SH-SY5Y, HepG2, HEK293 Cell Lines, and Human Lymphocytes