Autor:jmadunic

Autori: Antonio Zandona, Lucija Marcelić, Suzana Žunec, Josip Madunić, Maja Katalinić Sažetak radaHaving a broad spectrum of biological and pharmacological activities, including anticholinergic, antihistaminic, antiparasitic, antioxidant, and antitumour, quinuclidine derivatives have piqued much interest in the field of drug discovery and biomedical research. This study investigates the oxidative stress effects of six N‐alkyl quaternary quinuclidine derivatives, namely …
Nastavite čitati Effects of N‐alkyl quaternary quinuclidines on oxidative stress biomarkers in SH-SY5Y cells

Autori: Ruihong Zhu, Yiyun Liu, Yongchao Ma, Tong Xu, Guanglei Yang, Antonio Zandona, Tena Čadež, Zrinka Kovarik, Heidi Qunhui Xie, Li Xu, Bin Zhao Sažetak radaEnvironmental contaminants, such as pesticides, can inhibit the enzymatic activity of acetylcholinesterase (AChE), an enzyme necessary for neurotransmission. The inhibitory effects of structurally diverse pesticides on AChE may result from either reversible or covalent interactions. Therefore, assessing their potency typically requires different assay design to determine either dissociation constants or rate constants, …
Nastavite čitati Simplified assessment of acetylcholinesterase inhibition by environmental organophosphorus pesticides

Autori: Irena Škorić, Maja Sviben, Milena Mlakić, Tena Čadež, Nikolina Maček Hrvat, Zrinka Kovarik Sažetak radaThe development of small-molecule ligands targeting cholinesterases remains a central focus in neuropharmacology, particularly for the treatment of neurodegenerative disorders and organophosphate poisoning. This review highlights the rational design, synthesis, and biological profiling of diverse classes of heterocyclic compounds – including …
Nastavite čitati Photochemistry-driven design of small molecule cholinesterase ligands

Autori: Antonio Zandona, Andreja Jurič, Blanka Tariba Lovaković, Alica Pizent, Dubravka Rašić, Nevenka Kopjar, Maja Katalinić, Arnes Rešić, Irena Canjuga, Marijana Neuberg, Goran Kozina, Ana Lucić Vrdoljak, Irena Brčić Karačonji Sažetak radaAmphetamine-type stimulants (ATSs) are widely abused substances that impair central and peripheral nervous system functions. The mechanisms of their toxicity on human neuronal cells have …
Nastavite čitati Exposure of human neuroblastoma SH-SY5Y cells to amphetamine-type stimulants leads to oxidative-antioxidative imbalance associated with DNA damage and acetylcholine antagonism

Autori: Ana-Marija Lulić, Lucija Marcelić, Alma Ramić, Andreja Radman Kastelic, Antonio Zandona, Nikola Maraković, Ines Primožič, Maja Katalinić Sažetak radaIn this study, we investigated the inhibitory activity of novel dodecylaminoquinuclidines (QAs) on neurotransmitter-hydrolyzing enzymes, specifically acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Following our previous findings, we modified the structure of a lead compound to develop more potent …
Nastavite čitati Cholinesterase activity modulators: Evaluation of dodecylaminoquinuclidines as inhibitors of human AChE and BChE

Autori: Ana Barbarić, Lara Saftić Martinović, Zvonimir Marijanović, Lea Juretić, Andreja Jurič, Danijela Petrović, Violeta Šoljić, Ivana Gobin Sažetak radaHoneydew honey (HH) is a distinctive type of honey known for its dark colour, high mineral and polyphenol content, and pronounced biological activity. This study continues previous research on beech and chestnut honeydew honeys by presenting a …
Nastavite čitati Integrated Chemical and Biological Evaluation of Linden Honeydew Honey from Bosnia and Herzegovina: Composition and Cellular Effects

Autori: Suzana Žunec, Marija Kuzmić, Andreja Jurič, Irena Brčić Karačonji, Ana Lucić Vrdoljak, Nevenka Kopjar Sažetak radaIntroduction: Ultraviolet B (UVB) radiation is a physical agent ubiquitously present in the environment that triggers inflammatory processes, oxidative stress, and DNA instability, potentially leading to various pathological conditions and diseases. In this study, we assessed whether Croatian certified organic …
Nastavite čitati The protective effect of chestnut honey against oxidative stress and cyto/genotoxicity produced by UVB irradiation established in vitro