Autor:jmadunic

Autori: Elizabeta Zandona, Maja Vukelić, Karla Hanousek Čiča, Antonio Zandona, Jasna Mrvčić, Maja Katalinić, Ines Cindrić, Almir Abdurramani, Irena Barukčić Jurina Sažetak radaThe food industry generates large quantities of biowaste, including olive (Olea europaea L.) leaves, which are rich in phenolic compounds with proven antioxidant and antimicrobial activity. In this study, a microwave-assisted olive leaf extract was …
Nastavite čitati Bioactive Properties of the Microwave-Assisted Olive Leaf Extract and Its Incorporation into a Whey Protein Isolate Coating of Semi-Hard Cheese

Autori: Antonio Zandona, Matea Jurić, Ludovic Jean, Pierre-Yves Renard, Maja Katalinić Sažetak radaTetrahydroisoquinoline (THIQ) oximes have been investigated as antidotes for poisoning by toxic organophosphorus compounds. Recent studies have shown that some THIQ oximes induce cytotoxic effects and trigger apoptosis in various cell types. Since this pathway activation is desirable for anticancer drugs, we further explored the …
Nastavite čitati Assessment of cytotoxic properties of tetrahydroisoquinoline oximes in breast, prostate and glioblastoma cancer cells

Autori: Antonio Zandona, Anikó Szecskó, Suzana Žunec, Ivana Novak Jovanović, Valentina Bušić, Dajana Gašo Sokač, Mária A. Deli, Maja Katalinić, Szilvia Veszelka Sažetak radaNicotinamides play a crucial role in energy metabolism and maintenance of the redox homeostasis counteracting oxidative stress and elevated reactive oxidative species (ROS) in human cells. The levels of nicotinamides decline with age and are associated with various pathologies, including ones linked with the blood-brain barrier disorder. Therefore, the …
Nastavite čitati Nicotinamide derivatives protect the blood-brain barrier against oxidative stress

Autori: Marko Gerić, Lucia Nanić, Vedran Micek, Ivana Novak Jovanović, Goran Gajski, Dubravka Rašić, Tatjana Orct, Marija Ljubojević, Dean Karaica, Jasna Jurasović, Ivana Vrhovac Madunić, Maja Peraica, Ivan Sabolić, Vanessa Moraes de Andrade, Davorka Breljak, Ivica Rubelj Sažetak radaBackground: Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate …
Nastavite čitati The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats

Autori: Mateo Jakac, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka, Nevenka Kopjar Sažetak radaPropolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since …
Nastavite čitati Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro

Autori: Tena Čadež, Nikolina Maček Hrvat, Goran Šinko, Jarosław Kalisiak, Zoran Radić, Valery V. Fokin, Karl Barry Sharpless, Palmer Taylor, Zrinka Kovarik Sažetak radaA library of 100 click-chemistry-derived oximes was evaluated as reactivators of butyrylcholinesterase (BChE) inhibited by the nerve agents (NAs) sarin, cyclosarin, VX, and tabun. While reactivation efficiency was highly dependent on the structure …
Nastavite čitati Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging

Autori: Irena Brčić Karačonji, Tea Jelača, Andreja Jurič, Ana Lucić Vrdoljak Sažetak radaOpiates such as morphine and codeine are substances often misused to improve the performance of racing horses during competitions and are therefore on the International Federation for Equestrian Sports’ list of prohibited substances. However, a positive antidoping test may be due to the consumption …
Nastavite čitati Morphine and codeine in racing horse feed: is there reason for concern?